GSE103242

syn77114579

Created By Aditya Nath aditya.nath

doi: 10.1158/0008-5472.CAN-17-1327
title: The transcriptome effect of overexpressing EZH2 in MCF7
funder: NIH-NCI
series:
authors: Wu Yanming Zhang Zhao Xu Kexin
creator: Wu Yanming Zhang Zhao Xu Kexin
license: CC-BY 4.0
species: Homo sapiens
studyId: syn9773346
subject: MCF-7
ageGroup:
citation: Wu Y et al. (2018). Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis. Cancer Res. 78(3):671-684. doi: 10.1158/0008-5472.CAN-17-1327
dataType: gene expression
keywords: MCF-7
accessType: Open Access
contributor:
description: Purpose: Increasing evidence suggests that epigenetic reprogramming contributes significantly to the development of endocrine therapy resistance in breast cancer. The goal of this work is to explore how the histone methyltransferase EZH2 interacts with ER signaling and drives the insensitiveness of breast cancer cells to the antagonistic effect of tamoxifen on ER activity. Therefore, we comprehensively analyzed the transcriptional program regulated by EZH2 in EZH2 overexpressed MCF-7 cells. ...
grantNumber: CA217297
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE103242
manifestation:
specimenCount: 12
yearProcessed: 2017
countryOfOrigin:
individualCount: 12
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE103242
includedInDataCatalog:

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