GSE101209

syn77110821

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-017-01556-7
title: Gene expression changes associated with high density collagen microenviroment in cancer cells
funder: NIH-NCI
series:
creator: Ortiz Daniel Fraley Stephanie
license: CC-BY 4.0
species: Homo sapiens
studyId: syn10140998
subject:
ageGroup:
citation: Velez DO et al. (2017). 3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry. Nat Commun. 8(1):1651. doi: 10.1038/s41467-017-01556-7
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: We report RNA sequencing data from 2 cancer cell line (fibrosarcoma, HT1080 and Breast cancer, MDA-MB-231) and one non-canceours cell line (human foreskin fibroblast HFF) embbeded in two different 3D collagen matrix environements. The topographical organization of collagen within the tumor ECM has been implicated in guiding cancer cell migration and independently predicts progression to metastasis. Here, we show that collagen matrices with small pores and short fibers, but not Matrigel, trigg...
grantNumber: CA209891
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE101209
manifestation:
specimenCount: 18
yearProcessed: 2017
countryOfOrigin:
individualCount: 18
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE101209
includedInDataCatalog:

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