GSE109089

syn77110686

Created By Aditya Nath aditya.nath

doi: 10.1016/j.stem.2018.03.012
title: A CLK3-HMGA2 alternative splicing axis impacts human hematopoietic stem cell molecular identity throughout development [HSC and PROG RNA-seq]
funder: NIH-NCI
series:
creator: Guo Michael Cacchiarelli Davide Cesana Marcella
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7315802
subject:
ageGroup:
citation: Cesana M et al. (2018). A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development. Cell Stem Cell. 22(4):575-588.e7. doi: 10.1016/j.stem.2018.03.012
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: While gene expression dynamics have been extensively catalogued during hematopoietic differentiation in the adult, less is known about transcriptome diversity of human hematopoietic stem cells (HSCs) during development. To characterize transcriptional and post-transcriptional changes in HSCs during development, we leveraged high-throughput genomic approaches to profile miRNAs, lincRNAs, and mRNAs. Our findings indicate that HSCs manifest distinct alternative splicing patterns in key hematopoi...
grantNumber: CA209997
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE109089
manifestation:
specimenCount: 21
yearProcessed: 2018
countryOfOrigin:
individualCount: 21
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE109089
includedInDataCatalog:

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