GSE101988

syn77106997

Created By Aditya Nath aditya.nath

doi: 10.1016/j.cell.2018.05.009
title: Acid suspends the circadian clock in hypoxia through inhibition of mTOR
funder: NIH-NCI
series:
creator: Walton Zandra Brooks Rebekah Zhang Lin Dang Chi
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349753
subject: U-2 OS
ageGroup:
citation: Walton ZE et al. (2018). Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. 174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009
dataType: gene expression
keywords: U-2 OS osteosarcoma
accessType: Open Access
contributor:
description: Recent reports indicate hypoxia influences the clock through the transcriptional activities of hypoxia inducible factors (HIFs) at clock genes. Unexpectedly, we uncover a profound disruption of the circadian clock and diurnal transcriptome when hypoxic cells are permitted to acidify, recapitulating the tumor microenvironment. Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation. Acidification of several human and murine cell lines, as well a...
grantNumber: CA193489
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE101988
manifestation:
specimenCount: 26
yearProcessed: 2017
countryOfOrigin:
individualCount: 26
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE101988
includedInDataCatalog:

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