GSE100274

syn77106989

Created By Aditya Nath aditya.nath

doi: 10.1186/s12915-018-0527-2
title: Chemically Induced Paneth Cells Provide Superior In Vivo Mimic to Organoid-derived Analog
funder: NIH-NCI
series:
authors: Ordovas-Montanes Jose Shalek Alex
creator: Ordovas-Montanes Jose Shalek Alex
license: CC-BY 4.0
species: Mus musculus
studyId: syn9773338
subject:
ageGroup:
citation: Mead BE et al. (2018). Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types. BMC Biol. 16(1):62. doi: 10.1186/s12915-018-0527-2
dataType: gene expression
keywords: Intestinal organoids
accessType: Open Access
contributor:
description: Paneth cells (PCs) are post-mitotic secretory cells of the small intestine that produce antimicrobials, growth factors, and cytokines. Multiple diseases have been linked to alterations in PC function. Past studies of PCs have relied on in vivo models, and limited in vitro models, including organoids. While useful, whether the in vitro models recapitulate in vivo biology is an important, yet unanswered question. Here, we present a bona fide in vitro PC-enriched population derived via chemicall...
grantNumber: CA217377
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE100274
manifestation:
specimenCount: 3
yearProcessed: 2017
countryOfOrigin:
individualCount: 3
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE100274
includedInDataCatalog:

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