GSE114300

syn77105526

Created By Aditya Nath aditya.nath

doi: 10.1172/jci.insight.96836
title: Systematic immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival.
funder: NIH-NCI
series:
creator: Mittal Vivek Markowitz Geoffrey
license: CC-BY 4.0
species: Mus musculus
studyId: syn9775595
subject: C57BL/6
ageGroup:
citation: Markowitz GJ et al. (2018). Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival. JCI Insight. 3(13):. doi: 10.1172/jci.insight.96836
dataType: gene expression
keywords: C57BL/6
accessType: Open Access
contributor:
description: Success of immune checkpoint inhibitors in advanced non-small cell lung cancer (NSCLC) has invigorated their use in neo-adjuvant setting for early-stage disease. However, the cellular and molecular mechanisms of the early immune responses to therapy remain poorly understood. Through an integrated analysis of early-stage NSCLC patients and a Kras-mutant mouse model, we show a prevalent programmed cell death 1/ programmed cell death 1 ligand 1 (PD-1/PD-L1) axis exemplified by increased intratum...
grantNumber: CA188388
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE114300
manifestation:
specimenCount: 62
yearProcessed: 2018
countryOfOrigin:
individualCount: 62
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE114300
includedInDataCatalog:

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