GSE114864

syn77105510

Created By Aditya Nath aditya.nath

doi: 10.1038/s41591-018-0116-5
title: Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses (ATAC-seq)
funder: NIH-NCI
series:
creator: Cañadas Israel Watanabe Hideo Barbie David
license: CC-BY 4.0
species: Homo sapiens
studyId: syn22116895
subject:
ageGroup:
citation: Cañadas I et al. (2018). Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. Nat Med. 24(8):1143-1150. doi: 10.1038/s41591-018-0116-5
dataType: chromatin activity
keywords: Small Cell Lung Cancer
accessType: Open Access
contributor:
description: Mesenchymal tumor subclones secrete cytokines that promote tumorigenesis and chemoresistance, but the mechanism that underlies this phenomenon remains poorly understood. Here we identify a de-repressed subclass of endogenous retroviruses (ERVs) that engage innate immune signaling in mesenchymal cancer cells. These Stimulated 3 Prime Antisense Retroviral Coding Sequences (SPARCS) are oriented inversely in 3’UTRs of certain interferon-inducible genes, generating dsRNA following IFN exposure. Se...
grantNumber: CA214381
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE114864
manifestation:
specimenCount: 6
yearProcessed: 2018
countryOfOrigin:
individualCount: 6
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ATAC-seq
externalRepositoryUri: geo:GSE114864
includedInDataCatalog:

GSE114864 page is loading…