GSE110644

syn77105491

Created By Aditya Nath aditya.nath

doi: 10.1172/jci.insight.120594
title: Preclinical model of obesity and ER-positive breast cancer
funder: NIH-NCI
series:
creator: Wellberg Elizabeth MacLean Paul Gillen Austin
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349770
subject:
ageGroup:
citation: Wellberg EA et al. (2018). FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation. JCI Insight. 3(14):. doi: 10.1172/jci.insight.120594
dataType: gene expression
keywords: Breast tumor xenograft
accessType: Open Access
contributor:
description: Here, we developed a mouse model of diet induced obesity that is graft competent. In this model, we grew an ER-positive breast cancer patient derived tumor. Following ovariectomy and estrogen deprivation therapy, tumors continued to grow in obese but not lean mice. RNAsequencing analysis was performed on tumors from estrogen-supplemented lean mice, and from lean and obese mice after estrogen deprivation. This analysis identified fibroblast growth factor receptor signaling as a potential d...
grantNumber: CA210184
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE110644
manifestation:
specimenCount: 15
yearProcessed: 2018
countryOfOrigin:
individualCount: 15
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE110644
includedInDataCatalog:

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