GSE114438

syn77105488

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-018-05036-4
title: A PDGFRα-driven mouse model of Glioblastoma reveals a Stathmin1-mediated mechanism of sensitivity to Vinblastine
funder: NIH-NCI
series:
creator: Jun Hyun-Jung Charest Al
license: CC-BY 4.0
species: Mus musculus
studyId: syn7349757
subject:
ageGroup:
citation: Jun HJ et al. (2018). A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 9(1):3116. doi: 10.1038/s41467-018-05036-4
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Glioblastoma multiforme (GBM) is an aggressive primary brain cancer that includes focal amplification of PDGFRα and for which there are no effective therapies. Herein, we report the development of a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of PDGFRα and the analysis of GBM signaling pathways using proteomics. We discovered the tubulin-binding protein Stathmin1 (STMN1) as a PDGFRα phospho-regulated target and that this mis-regulation conferred selective...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE114438
manifestation:
specimenCount: 9
yearProcessed: 2018
countryOfOrigin:
individualCount: 1
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA array
externalRepositoryUri: geo:GSE114438
includedInDataCatalog:

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