GSE118389

syn77102284

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-018-06052-0
title: Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq [RNA-Seq]
funder: NIH-NCI
series:
creator: Cristea Simona
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349757
subject:
ageGroup:
citation: Karaayvaz M et al. (2018). Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq. Nat Commun. 9(1):3588. doi: 10.1038/s41467-018-06052-0
dataType: gene expression
keywords: breast
accessType: Open Access
contributor:
description: Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conduct single-cell RNA- sequencing (scRNA-seq) of >1500 cells from six primary TNBC. Intercellular heterogeneity of gene expression programs within each tumor was variable and largely correlated with clonality of inferred genomic copy number changes, suggesting that genotype drives the gene expression phenotype of individual subpopulat...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE118389
manifestation:
specimenCount: 1534
yearProcessed: 2018
countryOfOrigin:
individualCount: 1534
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE118389
includedInDataCatalog:

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