GSE118303

syn77102272

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-018-06052-0
title: Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq [WES]
funder: NIH-NCI
series:
creator: Cristea Simona
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349757
subject: CEPH1408 lymphoblastoid cell line
ageGroup:
citation: Karaayvaz M et al. (2018). Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq. Nat Commun. 9(1):3588. doi: 10.1038/s41467-018-06052-0
dataType: genomic variants
keywords: breast CEPH1408 lymphoblastoid cell line
accessType: Open Access
contributor:
description: Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conduct single-cell RNA- sequencing (scRNA-seq) of >1500 cells from six primary TNBC, together with whole exome sequencing (WES) for four of the tumors. Intercellular heterogeneity of gene expression programs within each tumor was variable and largely correlated with clonality of inferred genomic copy number changes, suggesting that gen...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE118303
manifestation:
specimenCount: 5
yearProcessed: 2018
countryOfOrigin:
individualCount: 5
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: whole exome sequencing
externalRepositoryUri: geo:GSE118303
includedInDataCatalog:

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