GSE123628

syn77100281

Created By Aditya Nath aditya.nath

doi: 10.7554/eLife.39479
title: RNA-seq of Splenic CD4+ T cells and colon epithelial cells from miR-34a-/- and wildtype mice
funder: NIH-NCI
series:
creator: Wang Lihua Wang Ergang Wang Yi Mines Robert Xiang Kun Sun Zhiguo Zhou Gaiting Chen Kai-Yuan Rakhilin Nikolai Chao Shanshan Ye Gaoqi Wu Zhenzhen Yan Huiwen Shen Hong Everitt Jeffrey Bu Pengcheng Shen Xiling
license: CC-BY 4.0
species: Mus musculus
studyId: syn22116893
subject: C57BL/6
ageGroup:
citation: Wang L et al. (2018). miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis. Elife. 7():. doi: 10.7554/eLife.39479
dataType: gene expression
keywords: C57BL/6
accessType: Open Access
contributor:
description: miR-34a is a known tumor suppressor that targets cell proliferation and apoptosis genes. In this study, we have shown that miR-34a acts as a safeguard for the inflammatory stem cell niche and reparative regeneration by modulating both the immune and epithelial responses to infection and inflammation. We isolated CD4+ T cells and colon epithelial cells from miR-34a-/- and wildtype mice revealed various changes in gene expression.
grantNumber: CA214300
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE123628
manifestation:
specimenCount: 12
yearProcessed: 2018
countryOfOrigin:
individualCount: 12
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE123628
includedInDataCatalog:

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