GSE114071

syn77100148

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-018-07981-6
title: Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
funder: NIH-NCI
series:
creator: Wang Nayi Chen Zhuo Fan Rong Lu Jun
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7315810
subject:
ageGroup:
citation: Wang N et al. (2019). Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation. Nat Commun. 10(1):95. doi: 10.1038/s41467-018-07981-6
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Measuring multiple omics profiles from the same single cell opens up the opportunity to decode molecular regulation that underlies intercellular heterogeneity in development and disease. Here, we present co-sequencing of microRNAs and mRNAs in the same single cells using a half-cell genomics approach. This method demonstrates good robustness (~95% success rate) and reproducibility (R2=0.93 for both microRNAs and mRNAs), yielding paired half-cell microRNA and mRNA profiles that we can independ...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE114071
manifestation:
specimenCount: 42
yearProcessed: 2018
countryOfOrigin:
individualCount: 42
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE114071
includedInDataCatalog:

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