GSE110704

syn77098231

Created By Aditya Nath aditya.nath

doi:
title: DNA:cytoplasm ratio defines an upper limit to cell size [RNA-seq]
funder: NIH-NCI
series:
creator: Neurohr Gabriel Terry Rachel Moretto Fabien Miettinen Teemu Pontano Vaites Laura Soares Luis Paulo Joao Harper Wade Buratowski Stephen Manalis Scott van Werven Folkert Novak Bela Tyson John Amon Angelika
license: CC-BY 4.0
species: Saccharomyces cerevisiae Candida albicans
studyId: syn9773338
subject:
ageGroup:
citation:
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important is not understood. Here we show that growing beyond a certain size has wide-ranging effects on cell physiology. Large cells are defective in gene induction, cell cycle progression and cell signaling. We further show that these defects are caused by the inability of large cells to scale nucleic acid ...
grantNumber: CA217377
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE110704
manifestation:
specimenCount: 20
yearProcessed: 2018
countryOfOrigin:
individualCount: 20
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE110704
includedInDataCatalog:

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