GSE111075

syn77098227

Created By Aditya Nath aditya.nath

doi: 10.1016/j.cell.2019.01.018
title: DNA:cytoplasm ratio defines an upper limit to cell size [array]
funder: NIH-NCI
series:
creator: Neurohr Gabriel Amon Angelika
license: CC-BY 4.0
species: Saccharomyces cerevisiae Saccharomyces cerevisiae W303
studyId: syn9773338
subject:
ageGroup:
citation: Neurohr GE et al. (2019). Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence. Cell. 176(5):1083-1097.e18. doi: 10.1016/j.cell.2019.01.018
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important is not understood. Here we show that growing beyond a certain size has wide-ranging effects on cell physiology. Large cells are defective in gene induction, cell cycle progression and cell signaling. We further show that these defects are caused by the inability of large cells to scale nucleic acid ...
grantNumber: CA217377
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE111075
manifestation:
specimenCount: 8
yearProcessed: 2018
countryOfOrigin:
individualCount: 1
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA array
externalRepositoryUri: geo:GSE111075
includedInDataCatalog:

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