GSE104984

syn77097857

Created By Aditya Nath aditya.nath

doi: 10.1016/j.ccell.2018.10.014
title: KDM5B links cellular transcriptome heterogeneity to therapy resistance (Exome-Seq)
funder: NIH-NCI
series:
authors: Hinohara Kunihiko Wu Hua-Jun Michor Franziska Polyak Kornelia
creator: Hinohara Kunihiko Wu Hua-Jun Michor Franziska Polyak Kornelia
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349757
subject:
ageGroup:
citation: Hinohara K et al. (2018). KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance. Cancer Cell. 34(6):939-953.e9. doi: 10.1016/j.ccell.2018.10.014
dataType: genomic variants
keywords:
accessType: Open Access
contributor:
description: The KDM5B histone H3 lysine 4 (H3K4) demethylase has been implicated in therapy resistance in multiple cancer types including breast cancer, but the underlying mechanism is poorly defined. Here we show that inhibition of KDM5B activity increases sensitivity to anti-estrogens by modulating estrogen-receptor (ER) signaling. Conversely, acquired resistance to KDM5 inhibitors leads to gain of ER chromatin binding and estrogen-independent growth. Sequencing of barcoded cell populations and mathema...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE104984
manifestation:
specimenCount: 5
yearProcessed: 2017
countryOfOrigin:
individualCount: 5
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: whole exome sequencing
externalRepositoryUri: geo:GSE104984
includedInDataCatalog:

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