GSE119149

syn77096452

Created By Aditya Nath aditya.nath

doi: 10.1073/pnas.1812876116
title: Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells
funder: NIH-NCI
series:
creator: Kröger Cornelia Weinberg Robert
license: CC-BY 4.0
species: Homo sapiens
studyId: syn9775689
subject:
ageGroup:
citation: Kröger C et al. (2019). Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells. Proc Natl Acad Sci U S A. 116(15):7353-7362. doi: 10.1073/pnas.1812876116
dataType: gene expression
keywords: HMLER
accessType: Open Access
contributor:
description: Using the recently described CD104+/CD44hi antigen combination we demonstrate that tumorigenicity depends on individual cells residing in a hybrid E/M state. Acquisition of this E/M hybrid state is facilitated by the differential expression of EMT- TFs, like Snail accompanied by the expression of adult stem-cell programs. Transition from the highly tumorigenic E/M state to a fully mesenchymal phenotype, achieved by constitutive ectopic expression of Zeb1, is sufficient to drive cells out of t...
grantNumber: CA184897
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE119149
manifestation:
specimenCount: 12
yearProcessed: 2018
countryOfOrigin:
individualCount: 12
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE119149
includedInDataCatalog:

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