GSE121229

syn77096304

Created By Aditya Nath aditya.nath

doi: 10.1186/s13058-019-1132-1
title: BRCA1 Mutations Attenuate Super-Enhancer Function and Chromatin Looping in Haploinsufficient Human Breast Epithelial Cells
funder: NIH-NCI
series:
creator: Zhang Xiaowen Wang Yao Chiang Huai-Chin Li Rong
license: CC-BY 4.0
species: Homo sapiens
studyId: syn9773346
subject:
ageGroup:
citation: Zhang X et al. (2019). BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells. Breast Cancer Res. 21(1):51. doi: 10.1186/s13058-019-1132-1
dataType: chromatin activity
keywords: Primary human mammary epithelial cells (HMECs)
accessType: Open Access
contributor:
description: BRCA1 functions in multiple biological processes, including double-strand break repair, replication stress suppression, transcriptional regulation, and chromatin reorganization. While non-malignant cells carrying cancer-predisposing BRCA1 mutations exhibit increased genomic instability, it remains unclear whether BRCA1 haploinsufficiency affects transcription and chromatin dynamics. Here we show that primary mammary epithelial cells from women with BRCA1 mutations (BRCA1mut/+) display signifi...
grantNumber: CA217297
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE121229
manifestation:
specimenCount: 6
yearProcessed: 2018
countryOfOrigin:
individualCount: 6
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ChIP-seq
externalRepositoryUri: geo:GSE121229
includedInDataCatalog:

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