GSE125587

syn77096250

Created By Aditya Nath aditya.nath

doi: 10.1002/advs.201801531
title: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes
funder: NIH-NCI
series:
creator: Xiao Yang Fan Rong
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7315810
subject:
ageGroup:
citation: Xiao Y et al. (2019). Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes. Adv Sci (Weinh). 6(8):1801531. doi: 10.1002/advs.201801531
dataType: gene expression
keywords: brain Patient-derived glioblastoma stem-like cells
accessType: Open Access
contributor:
description: The perivascular niche (PVN) plays an essential role in brain tumor stem-like cell (BTSC) fate control, tumor invasion, and therapeutic resistance. We use a microvasculature-on-a-chip system as a PVN model to evaluate the ex vivo dynamics of BTSCs from ten glioblastoma patients. BTSCs were found to preferentially localize in the perivascular zone, where they exhibited either the lowest motility, as in quiescent cells, or the highest motility, as in the invasive phenotype, with migration over ...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE125587
manifestation:
specimenCount: 10
yearProcessed: 2019
countryOfOrigin:
individualCount: 10
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE125587
includedInDataCatalog:

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