GSE126770

syn77096108

Created By Aditya Nath aditya.nath

doi: 10.1016/j.immuni.2019.03.031
title: Natural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cells
funder: NIH-NCI
series:
creator: van der Veeken Joris Zhong Yi Sharma Roshan Mazutis Linas Duo Phuong Pe’er Dana Leslie Christina Rudensky Alexander
license: CC-BY 4.0
species: Mus musculus
studyId: syn7315805
subject:
ageGroup:
citation: van der Veeken J et al. (2019). Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells. Immunity. 50(5):1202-1217.e7. doi: 10.1016/j.immuni.2019.03.031
dataType: chromatin activity gene expression
keywords: Spleen
accessType: Open Access
contributor:
description: Stable changes in chromatin states and gene expression in cells of the immune system form the basis for their memory of infections and other challenges. We used naturally occurring cis-regulatory variation in wild-derived inbred mouse strains to explore the mechanisms underlying long-lasting vs. transient gene regulation in antigen-specific CD8 T cells responding to acute viral infection. Our observations provide novel insights into the mechanisms driving stable and reversible transcriptional...
grantNumber: CA209975
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE126770
manifestation:
specimenCount: 70
yearProcessed: 2019
countryOfOrigin:
individualCount: 70
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ATAC-seq ChIP-seq RNA-seq
externalRepositoryUri: geo:GSE126770
includedInDataCatalog:

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