GSE129392

syn77096085

Created By Aditya Nath aditya.nath

doi: 10.1158/0008-5472.CAN-18-3026
title: RNA-Seq comparison between BrafCA;Cdkn2af/f control and BrafCA;Cdkn2af/f; Arf6Q67L mouse tumors
funder: NIH-NCI
series:
creator: Grossmann Allie Yoo Jae
license: CC-BY 4.0
species: Mus musculus
studyId: syn9771796
subject:
ageGroup:
citation: Yoo JH et al. (2019). The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State. Cancer Res. 79(11):2892-2908. doi: 10.1158/0008-5472.CAN-18-3026
dataType: gene expression
keywords: melanoma tumor
accessType: Open Access
contributor:
description: We analyzed transcriptomes from BRAFV600E/CDKN2ANull + ARF6Q67L mouse melanoma tumors to identify novel ARF6-regulated target genes and pathways. A unique gene expression signature in the ARF6Q67L tumors included upregulated genes related to known ARF6-dependent cell functions in trafficking, cell adhesion, motility, providing an internal positive control that helps to validate the utility of RNA sequencing as a discovery tool for ARF6. Interestingly, mTOR signaling components were upregulat...
grantNumber: CA209978
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE129392
manifestation:
specimenCount: 10
yearProcessed: 2019
countryOfOrigin:
individualCount: 10
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE129392
includedInDataCatalog:

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