GSE114686

syn77094655

Created By Aditya Nath aditya.nath

doi: 10.1016/j.cels.2019.03.009
title: Total RNA profiles in response to four tyrosine kinase inhibitors in human induced pluripotent stem cell-derived cardiomyocytes
funder: NIH-NCI
series:
creator: Wang Huan Boswell Sarah Sheehan Robert Sorger Peter
license: CC-BY 4.0
species: Homo sapiens
studyId: syn12051865
subject:
ageGroup:
citation: Wang H et al. (2019). Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming. Cell Syst. 8(5):412-426.e7. doi: 10.1016/j.cels.2019.03.009
dataType: gene expression
keywords: human induced pluripotent stem cell-derived cardiomyocytes
accessType: Open Access
contributor:
description: To define molecular markers of tyrosine kinase inhibitor-induced cardiotoxicity, we measured transcriptome changes in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) treated with one of four tyrosine kinase inhibitors (Erlotinib, Lapatinib, Sorafenib, or Sunitinib) displaying a range of mild to severe cardiotoxicity or a vehicle-only control (DMSO). Gene expression changes were assessed at the cell population level using total RNA-seq, which measured levels of both mRNA...
grantNumber: CA225088
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE114686
manifestation:
specimenCount: 84
yearProcessed: 2018
countryOfOrigin:
individualCount: 84
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE114686
includedInDataCatalog:

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