GSE113616

syn77094258

Created By Aditya Nath aditya.nath

doi: 10.1016/j.cell.2019.05.012
title: Stromal Fibroblasts Drive Single Cell Heterogeneity in Pancreatic Cancer
funder: NIH-NCI
series:
creator: Ligorio Matteo Sil Srinjoy Misale Sandra Karabacak Murat Jordan Nicole Desai Niyati Arora Kshitij Kulkarni Anupriya Rajurkar Mihir Di Plato Mauro Boukhali Myriam Fatherree Jackson Tai Eric Vo Kevin Damon Leah Xega Kristina Desai Rushil Choz Melissa Bersani Francesca Thapar Vishal Rivera Miguel Deshpande Vikram Benes Cyril Maheswaran Shyamala Haber Daniel Fernandez-Del Castillo Carlos Ferrone Cristina Haas Wilhelm Aryee Martin Ting David
license: CC-BY 4.0
species: Homo sapiens
studyId: syn17084053
subject:
ageGroup:
citation: Ligorio M et al. (2019). Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell. 178(1):160-175.e27. doi: 10.1016/j.cell.2019.05.012
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: To understand the interplay between cancer and stroma, we performed single cell RNA-sequencing of PDAC cells admixed with stromal fibroblasts and defined different single cell populations with varying levels of proliferative and metastatic transcriptional states. PDAC cell behavior in vitro and in vivo on these phenotypic axes could be tuned with the proportion of stromal fibroblasts. These cell types were identified in human pancreatic tumors, and specific subpopulations were associated with...
grantNumber: CA215798
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE113616
manifestation:
specimenCount: 189
yearProcessed: 2018
countryOfOrigin:
individualCount: 189
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE113616
includedInDataCatalog:

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