GSE129521

syn77094212

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-019-10307-9
title: Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma (ChIP-seq)
funder: NIH-NCI
series:
authors: Beroukhim Rameen Bandopadhayay Pratiti
creator: Beroukhim Rameen Bandopadhayay Pratiti
license: CC-BY 4.0
species: Homo sapiens
studyId: syn12051865
subject:
ageGroup:
citation: Bandopadhayay P et al. (2019). Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nat Commun. 10(1):2400. doi: 10.1038/s41467-019-10307-9
dataType: chromatin activity
keywords:
accessType: Open Access
contributor:
description: BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and ultimately for resistance, have not been fully defined. Here, using a combination of expression profiling, genome-scale CRISPR/Cas9-mediated loss of function and ORF/cDNA driven rescue screens, and cell-based models of spontaneous resistance, we identify bHLH/homeobox transcription factors and cell-cycle regulators as key genes mediating BETi’s respon...
grantNumber: CA225088
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE129521
manifestation:
specimenCount: 22
yearProcessed: 2019
countryOfOrigin:
individualCount: 22
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ChIP-seq
externalRepositoryUri: geo:GSE129521
includedInDataCatalog:

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