GSE129127

syn77094017

Created By Aditya Nath aditya.nath

doi: 10.1038/s41556-019-0328-z
title: Patient-derived xenograft platform for metastatic melanoma: RNA sequencing of 95 melanoma PDX samples
funder: NIH-NCI
series:
creator: Krijgsman Oscar Kemper Kristel Peeper Daniel
license: CC-BY 4.0
species: Homo sapiens
studyId: syn10140998
subject:
ageGroup:
citation: Coppé JP et al. (2019). Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities. Nat Cell Biol. 21(6):778-790. doi: 10.1038/s41556-019-0328-z
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Although high clinical response rates are seen for immune checkpoint blockade (ICB) of metastatic melanoma, both intrinsic and acquired ICB resistance remain formidable challenges. Combination  ICB shows improved clinical benefit, but is associated with severe adverse events and exceedingly high cost. Therefore, there is a dire need to stratify individual patients for their likelihood of responding to either anti-PD-1 or anti-CTLA-4 monotherapy, or the combination. Since it is conceivable tha...
grantNumber: CA209891
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE129127
manifestation:
specimenCount: 95
yearProcessed: 2019
countryOfOrigin:
individualCount: 95
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE129127
includedInDataCatalog:

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