GSE113465

syn77092949

Created By Aditya Nath aditya.nath

doi: 10.1158/1078-0432.CCR-19-0596
title: Evaluation of HSP90 inhibitor expsosure on Immune Cell Gene Expression
funder: NIH-NCI
series:
creator: Jaeger Alex Gaglia Giorgio Whitesell Luke
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349764
subject:
ageGroup:
citation: Jaeger AM et al. (2019). Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation. Clin Cancer Res. 25(21):6392-6405. doi: 10.1158/1078-0432.CCR-19-0596
dataType: gene expression
keywords: pbmc
accessType: Open Access
contributor:
description: We report RNA-sequencing analysis of human peripheral blood mononuclear cells exposed to clinically recommended doses (500 nM) of the HSP90 inhibitor ganetispib. Global analysis of the expression profiles of treated cells revealed wide spread changes in gene expression, specifically, upregulation of protein folding and assembly pathways, with downregulation of antigen presentation through MHC Class I and Class I.
grantNumber: CA210180
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE113465
manifestation:
specimenCount: 4
yearProcessed: 2018
countryOfOrigin:
individualCount: 4
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE113465
includedInDataCatalog:

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