GSE129007

syn77092935

Created By Aditya Nath aditya.nath

doi: 10.1016/j.gpb.2019.03.002
title: Single-cell integrative analysis of CAR-T cell activation reveals a predominantly TH1/TH2 mixed response independent of differentiation
funder: NIH-NCI
series:
creator: Xhangolli Iva Xiao Yang Fan Rong
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7315810
subject: healthy donor
ageGroup:
citation: Xhangolli I et al. (2019). Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed T(H)1/T(H)2 Response Independent of Differentiation. Genomics Proteomics Bioinformatics. 17(2):129-139. doi: 10.1016/j.gpb.2019.03.002
dataType: gene expression
keywords: healthy donor Blood CAR-T cells
accessType: Open Access
contributor:
description: We present the first comprehensive portrait of single-cell level transcriptional and cytokine signatures of anti-CD19 4-1BB/CD28/CD3ζ CAR-T cells upon antigen-specific stimulation. Both CD4+ ‘helper’ and CD8+ cytotoxic CAR-T cells are equally effective in directly killing target tumor cells and their cytotoxic activity is associated with the elevation of a range of TH1 and TH2 signature cytokines (e.g., IFNγ, TNFα, IL5, and IL13), as confirmed by the expression of master transcription factors...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE129007
manifestation:
specimenCount: 3
yearProcessed: 2019
countryOfOrigin:
individualCount: 3
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE129007
includedInDataCatalog:

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