GSE125594

syn77092836

Created By Aditya Nath aditya.nath

doi: 10.1016/j.molcel.2019.06.010
title: A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer [ChIP-seq]
funder: NIH-NCI
series:
creator: Zhao Zhang Chi Zhu Zhijie Liu
license: CC-BY 4.0
species: Homo sapiens
studyId: syn9773346
subject:
ageGroup:
citation: Zhu C et al. (2019). A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer. Mol Cell. 75(4):791-806.e8. doi: 10.1016/j.molcel.2019.06.010
dataType: chromatin activity
keywords: Breast cancer cell line
accessType: Open Access
contributor:
description: Estrogen and estrogen receptor alpha (ERα) signaling plays an essential role in ERα-positive breast cancer. ERα mainly occupies on distal enhancers within genome and requires the cooperation of additional co-factors to tune the enhancer activity. Through in vivo proximity-dependent labeling technique BioID, we identified YAP1 and TEAD4 protein as novel co-regulators of ERα. YAP and TEAD are nuclear effectors of the Hippo pathway regulating cell proliferation, organ size and tumorigenesis. The...
grantNumber: CA217297
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE125594
manifestation:
specimenCount: 29
yearProcessed: 2019
countryOfOrigin:
individualCount: 29
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ChIP-seq
externalRepositoryUri: geo:GSE125594
includedInDataCatalog:

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