GSE116081

syn77092784

Created By Aditya Nath aditya.nath

doi: 10.1126/scitranslmed.aaw4993
title: The androgen receptor regulates a druggable translational regulon in advanced prostate cancer [RNA-seq]
funder: NIH-NCI
series:
authors: Liu Yuzhen Horn Jessie Banda Kalyan Goodman Asha Lim Yiting Jana Sujata Arora Sonali Germanos Alexandre Yang Yu Coleman Ilsa Tharakan Robin Cai Elise Uo Takuma Pillai Smitha Corey Eva Morrissey Colm Chen Yu Carver Brett Plymate Stephen Beronja Slobodan Nelson Peter Hsieh Andrew
creator: Liu Yuzhen Horn Jessie Banda Kalyan Goodman Asha Lim Yiting Jana Sujata Arora Sonali Germanos Alexandre Yang Yu Coleman Ilsa Tharakan Robin Cai Elise Uo Takuma Pillai Smitha Corey Eva Morrissey Colm Chen Yu Carver Brett Plymate Stephen Beronja Slobodan Nelson Peter Hsieh Andrew
license: CC-BY 4.0
species: Mus musculus
studyId: syn35270581
subject:
ageGroup:
citation: Liu Y et al. (2019). The androgen receptor regulates a druggable translational regulon in advanced prostate cancer. Sci Transl Med. 11(503):. doi: 10.1126/scitranslmed.aaw4993
dataType: gene expression
keywords: prostate PB-Cre4;PTENLoxP/LoxP
accessType: Open Access
contributor:
description: The recent advent of highly potent inhibitors of the androgen receptor and androgen biosynthesis has had the unfortunate iatrogenic effect of fueling new lethal prostate cancer phenotypes in patients. In particular, non-neuroendocrine androgen receptor-low castration resistant prostate cancer (AR low CRPC) is increasing in occurrence amongst patients and is uniformly fatal. The mechanisms that promote this phenotype remain poorly understood. Through molecular studies of murine and human model...
grantNumber: CA224044
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE116081
manifestation:
specimenCount: 6
yearProcessed: 2018
countryOfOrigin:
individualCount: 6
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: in vivo tumor growth RNA-seq
externalRepositoryUri: geo:GSE116081
includedInDataCatalog:

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