GSE124494

syn77092752

Created By Aditya Nath aditya.nath

doi: 10.1016/j.immuni.2019.06.027
title: Single-cell survey of human lymphatics unveils marked endothelial cell heterogeneity and mechanisms of homing for neutrophils
funder: NIH-NCI
series:
creator: Takeda Akira Jalkanen Sirpa
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7315808
subject:
ageGroup:
citation: Takeda A et al. (2019). Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils. Immunity. 51(3):561-572.e5. doi: 10.1016/j.immuni.2019.06.027
dataType: gene expression
keywords: LN CD45- PDPN+ CD31+ cells
accessType: Open Access
contributor:
description: Lymphatic vessels form a critical component in the regulation of human health and disease. While their functional significance is increasingly being recognized, the comprehensive heterogeneity of lymphatics remains uncharacterized. Here, we report the profiling of 33,000 lymphatic endothelial cells (LECs) in human lymph nodes (LNs) by single-cell RNA sequencing. Unbiased clustering revealed six major types of human LECs. LECs lining the sub-capsular sinus (SCS) of LNs abundantly expressed neu...
grantNumber: CA209971
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE124494
manifestation:
specimenCount: 6
yearProcessed: 2018
countryOfOrigin:
individualCount: 6
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE124494
includedInDataCatalog:

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