GSE132926

syn77092732

Created By Aditya Nath aditya.nath

doi: 10.1016/j.cell.2019.07.044
title: Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells [RNA-Seq]
funder: NIH-NCI
series:
creator: Chow Ryan Chen Sidi
license: CC-BY 4.0
species: Mus musculus
studyId: syn7315810
subject: C57BL/6J, OT-1; Cas9
ageGroup:
citation: Dong MB et al. (2019). Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells. Cell. 178(5):1189-1204.e23. doi: 10.1016/j.cell.2019.07.044
dataType: gene expression
keywords: CD8 T cells C57BL/6J, OT-1; Cas9
accessType: Open Access
contributor:
description: CD8+ cytotoxic T cells play essential roles in anti-tumor immune responses. Here, we performed in vivo screens in CD8+ T cells and identified regulators of tumor infiltration and killing, which are directly relevant to cancer immunotherapy. Unlike in vitro screens, the in vivo screen robustly re-identified canonical immunotherapy targets such as PD-1 and Tim-3, along with genes that have not been characterized in T cells. The infiltration and degranulation screens converged on an RNA helicase...
grantNumber: CA209992
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE132926
manifestation:
specimenCount: 8
yearProcessed: 2019
countryOfOrigin:
individualCount: 8
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE132926
includedInDataCatalog:

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