GSE122336

syn77092672

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-019-11729-1
title: Single-cell profiling guided combinatorial immunotherapy for breast cancer resistance to Her2/neu and CDK4/6 targeted therapy
funder: NIH-NCI
series:
creator: Wang Qingfei Zhang Siyuan
license: CC-BY 4.0
species: Mus musculus
studyId: syn9771796
subject:
ageGroup:
citation: Wang Q et al. (2019). Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer. Nat Commun. 10(1):3817. doi: 10.1038/s41467-019-11729-1
dataType: gene expression
keywords: MMTV-neu202Mul
accessType: Open Access
contributor:
description: Trastuzumab (Herceptin™), a humanized monoclonal antibody targeting the extracellular domain of human epidermal growth factor receptor-2 (HER2), is one of the most successful examples of targeted therapies for HER2-positive breast cancer. However, drug resistance remains daunting challenges. New combinatorial regimen of CDK4/6 inhibitors plus trastuzumab is currently under active clinical investigations. In this study, we seek to prospectively model the in vivo response to CDK4/6 inhibitor Pa...
grantNumber: CA209978
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE122336
manifestation:
specimenCount: 21
yearProcessed: 2018
countryOfOrigin:
individualCount: 21
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE122336
includedInDataCatalog:

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