GSE114011

syn77092593

Created By Aditya Nath aditya.nath

doi: 10.1038/s41586-019-1526-3
title: E-cadherin suppresses invasion and promotes metastasis in multiple breast cancer models
funder: NIH-NCI
series:
creator: Ewald Andrew Bader Joel
license: CC-BY 4.0
species: Mus musculus
studyId: syn7349766
subject: FVB/NJ
ageGroup:
citation: Padmanaban V et al. (2019). E-cadherin is required for metastasis in multiple models of breast cancer. Nature. 573(7774):439-444. doi: 10.1038/s41586-019-1526-3
dataType: gene expression
keywords: mammary tumor FVB/NJ
accessType: Open Access
contributor:
description: E-cadherin (E-cad) mediates cell-cell adhesion and has been proposed to suppress both invasion and metastasis. However, invasive ductal cancers retain E-cad expression in the primary tumor, circulating tumor cells, and distant metastases. We recently demonstrated that cancer cell clusters are efficient metastatic seeds. Since clusters organize through cell-cell adhesion, we tested the requirement for E-cad in genetically engineered mouse models of luminal and basal breast cancer. Loss of E-ca...
grantNumber: CA210173
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE114011
manifestation:
specimenCount: 9
yearProcessed: 2018
countryOfOrigin:
individualCount: 9
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE114011
includedInDataCatalog:

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