GSE134583

syn77092577

Created By Aditya Nath aditya.nath

doi: 10.1016/j.stem.2019.08.003
title: Stag1 and Stag2 regulate cell fate decisions in hematopoiesis through non-redundant topological control [I]
funder: NIH-NCI
series:
creator: Viny Aaron Levine Ross Koche Richard
license: CC-BY 4.0
species: Mus musculus
studyId: syn7349742
subject:
ageGroup:
citation: Viny AD et al. (2019). Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation. Cell Stem Cell. 25(5):682-696.e8. doi: 10.1016/j.stem.2019.08.003
dataType: chromatin activity
keywords:
accessType: Open Access
contributor:
description: Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show Stag2 deletion in hematopoietic stem/progenitor cells (HSPC) results in altered hematopoietic function, increased self-renewal, and impaired differentiation. ChIP-sequencing revealed that while Stag2 and Stag1 bind a shared set of genomic loci, a component of Stag2 binding sites are uno...
grantNumber: CA193419
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE134583
manifestation:
specimenCount: 7
yearProcessed: 2019
countryOfOrigin:
individualCount: 7
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ChIP-seq
externalRepositoryUri: geo:GSE134583
includedInDataCatalog:

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