GSE137300

syn77091919

Created By Aditya Nath aditya.nath

doi: 10.1073/pnas.1907660116
title: Immune effector monocyte - neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer
funder: NIH-NCI
series:
creator: Hargerling Catharina Werb Zena Gonzalez Hugo
license: CC-BY 4.0
species: Mus musculus
studyId: syn9774783
subject: NOD/scid
ageGroup:
citation: Hagerling C et al. (2019). Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer. Proc Natl Acad Sci U S A. 116(43):21704-21714. doi: 10.1073/pnas.1907660116
dataType: gene expression
keywords: NOD/scid
accessType: Open Access
contributor:
description: Metastatic behaviour varies significantly among breast cancers. Mechanisms explaining why the majority of breast cancer patients never develop metastatic outgrowth are largely lacking but could underlie the development of novel immunotherapeutic target molecules. Here we show interplay between non-metastatic primary breast cancer and innate immune response, acting together to control metastatic progression. The primary tumor systemically recruits IFNγ-producing immune effector monocytes to th...
grantNumber: CA199315
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE137300
manifestation:
specimenCount: 10
yearProcessed: 2019
countryOfOrigin:
individualCount: 10
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE137300
includedInDataCatalog:

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