GSE136628

syn77091490

Created By Aditya Nath aditya.nath

doi: 10.1038/s41556-019-0404-4
title: Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
funder: NIH-NCI
series:
creator: Rodrigues Goncalo Lyden David
license: CC-BY 4.0
species: Mus musculus
studyId: syn7349757
subject:
ageGroup:
citation: Rodrigues G et al. (2019). Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nat Cell Biol. 21(11):1403-1412. doi: 10.1038/s41556-019-0404-4
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic colonization and demonstrate that pre-conditioning the brain microenvironment with exosomes from brain metastatic cells enhances cancer cell outgrowth. Proteomic analysis identified cell migration-inducing and hyaluronan-binding protein (CEMIP) as elevated i...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE136628
manifestation:
specimenCount: 24
yearProcessed: 2019
countryOfOrigin:
individualCount: 24
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE136628
includedInDataCatalog:

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