GSE136299

syn77091346

Created By Aditya Nath aditya.nath

doi: 10.1038/s41559-019-1046-4
title: Evolved Levels of Placental Invasion in Human and Bovine Endometrial Stroma
funder: NIH-NCI
series:
creator: Wagner Günter Gupta Kshitiz
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7315810
subject:
ageGroup:
citation: Kshitiz et al. (2019). Evolution of placental invasion and cancer metastasis are causally linked. Nat Ecol Evol. 3(12):1743-1753. doi: 10.1038/s41559-019-1046-4
dataType: gene expression
keywords: Endometrial Stromal Fibroblasts
accessType: Open Access
contributor:
description: Among mammals, the extent of placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (e.g. humans) are more vulnerable to malignancy, whereas animals with a non-invasive placenta (e.g. ruminants) are less likely to develop malignant cancer. To explain this correlation,we propose the hypothesis of Evolved Levels ofInvasibility (ELI) positing that the permissiveness of stromal tissue to invasion is a unitary character affecting both placental a...
grantNumber: CA209992
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE136299
manifestation:
specimenCount: 12
yearProcessed: 2019
countryOfOrigin:
individualCount: 12
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE136299
includedInDataCatalog:

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