GSE124227

syn77090842

Created By Aditya Nath aditya.nath

doi: 10.1038/s41588-019-0554-0
title: ARID1A is a critical regulator of luminal identity and therapeutic response in oestrogen receptor-positive breast cancer (RNA-Seq)
funder: NIH-NCI
series:
creator: Toska Eneda Chhangawala Sagar
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7315805
subject: MCF-7
ageGroup:
citation: Xu G et al. (2020). ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nat Genet. 52(2):198-207. doi: 10.1038/s41588-019-0554-0
dataType: gene expression
keywords: MCF-7
accessType: Open Access
contributor:
description: Mutations in ARID1A, a subunit of the SWI/SNF chromatin remodelling complex, are the most common somatic alteration of the SWI/SNF complex across all cancers including oestrogen receptor positive (ER)+ breast cancer. We have recently reported that ARID1A inactivating mutations are present at a high frequency in advanced endocrine resistant ER+ breast cancer. In parallel, to identify mechanisms of resistance to endocrine therapy in breast cancer, we performed an epigenome CRISPR/CAS9 knockout ...
grantNumber: CA209975
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE124227
manifestation:
specimenCount: 10
yearProcessed: 2018
countryOfOrigin:
individualCount: 10
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ATAC-seq in silico synthesis ChIP-seq immunoassay Sanger sequencing flow cytometry next-generation sequencing RNA-seq in vivo tumor growth quantitative PCR
externalRepositoryUri: geo:GSE124227
includedInDataCatalog:

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