GSE109750

syn77090695

Created By Aditya Nath aditya.nath

doi: 10.1016/j.cell.2019.12.024
title: Astrocytic trans-differentiation completes a multicellular paracrine feedback loop required for medulloblastoma tumor growth
funder: NIH-NCI
series:
creator: Zong Hui Yao Maojin
license: CC-BY 4.0
species: Mus musculus
studyId: syn17084062
subject: C57BL/6
ageGroup:
citation: Yao M et al. (2020). Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth. Cell. 180(3):502-520.e19. doi: 10.1016/j.cell.2019.12.024
dataType: gene expression
keywords: C57BL/6
accessType: Open Access
contributor:
description: We report the application of RNA-sequencing technology for high-throughput profiling of tumor-associated microglia/macrophage (TAMs). First, we checked the purity of sample by qRT-PCR. We confirmed the high purity of TAMs with rare other cell type contamination. By profiling samples of TAMs purified from five individual medulloblastoma of mouse model, we find that TAMs maintain microglia gene signature even there are decrease of microglia genes and increase of macrophage genes. This study pro...
grantNumber: CA215794
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE109750
manifestation:
specimenCount: 8
yearProcessed: 2018
countryOfOrigin:
individualCount: 8
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE109750
includedInDataCatalog:

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