GSE119999

syn77086542

Created By Aditya Nath aditya.nath

doi: 10.1038/s41594-020-0372-1
title: CRISPR knockout screening data and RNAsequencing in LINE-1(+) RPE cells
funder: NIH-NCI
series:
creator: Ardeljan Daniel Steranka Jared Li Zhi Taylor Martin Liu Chunhong Payer Lindsay Sarnecki Jacob Wu Pei-Hsun Hruban Ralph Boeke Jef Fenyö David Smogorzewska Agata Holland Andrew Burns Kathleen
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349766
subject:
ageGroup:
citation: Ardeljan D et al. (2020). Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication. Nat Struct Mol Biol. 27(2):168-178. doi: 10.1038/s41594-020-0372-1
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: CRISPR knockout screens were performed in RPE cells with or without wildtype p53 function to determine the genetic fitness interactions that occur upon induction of LINE-1 protein expression. We also performed RNAseq analysis in wildtype p53 RPE cells expressing LINE-1 or Luciferase control to determine transcriptomic changes that occur upon LINE-1 expression.
grantNumber: CA210173
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE119999
manifestation:
specimenCount: 46
yearProcessed: 2018
countryOfOrigin:
individualCount: 46
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE119999
includedInDataCatalog:

GSE119999 page is loading…