GSE123837

syn77081123

Created By Aditya Nath aditya.nath

doi: 10.1038/s41556-020-0477-0
title: Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing
funder: NIH-NCI
series:
creator: Lawson Devon Davis Ryan
license: CC-BY 4.0
species: Homo sapiens
studyId: syn9774783
subject:
ageGroup:
citation: Davis RT et al. (2020). Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nat Cell Biol. 22(3):310-320. doi: 10.1038/s41556-020-0477-0
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Although metastasis remains the cause of most cancer-related mortality, mechanisms governing seeding in distal tissues are poorly understood. Here we establish a robust method for identification of global transcriptomic changes in rare metastatic cells during seeding using single-cell RNA-sequencing and patient-derived xenograft (PDX) models of breast cancer. We find that both primary tumours and micrometastases display transcriptional heterogeneity, but micrometastases harbor a distinct tran...
grantNumber: CA199315
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE123837
manifestation:
specimenCount: 1707
yearProcessed: 2018
countryOfOrigin:
individualCount: 1707
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE123837
includedInDataCatalog:

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