GSE116391

syn77081076

Created By Aditya Nath aditya.nath

doi:
title: Mutations in splicing factor SF3B1 promote transformation through MYC stabilization
funder: NIH-NCI
series:
creator: Yoshimi Akihide Fabbri Giulia
license: CC-BY 4.0
species: Homo sapiens Mus musculus
studyId: syn7349759
subject:
ageGroup:
citation:
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Although mutations in the RNA splicing factor SF3B1 are frequently observed in multiple human cancers, their functional role in promoting tumorigenesis and therapeutic significance remain poorly understood. Here we characterize the splicing landscape of 79 tumors and 12 isogenic cell lines harboring SF3B1 hotspot mutations, identifying hundreds of cryptic 3’ splice site (ss) events shared as well as specific to different tumor types. Regulatory network analysis shows that tumors harboring the...
grantNumber: CA193313
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE116391
manifestation:
specimenCount: 16
yearProcessed: 2018
countryOfOrigin:
individualCount: 16
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE116391
includedInDataCatalog:

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