GSE115895

syn77081043

Created By Aditya Nath aditya.nath

doi: 10.1038/s41588-020-0602-9
title: Dynamic 3D chromosomal landscapes in acute leukemia [RNA-Seq]
funder: NIH-NCI
series:
creator: Kloetgen Andreas Thandapani Palaniraja Ntziachristos Panagiotis Aifantis Ioannis Tsirigos Aristotelis
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349742
subject: T cell acute lymphoblastic leukemia
ageGroup:
citation: Kloetgen A et al. (2020). Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia. Nat Genet. 52(4):388-400. doi: 10.1038/s41588-020-0602-9
dataType: gene expression
keywords: T cell acute lymphoblastic leukemia Peripheral blood primary T-ALL cells
accessType: Open Access
contributor:
description: Background: Disruptions of 3D chromatin architecture can alter the activity of topologically associated domains (TADs), rewire enhancer-promoter interactions and thus significantly impact gene regulatory programs. Recently, such disruptions have been implicated in tumorigenesis, highlighting the need for a deeper understanding of their detailed role. Methods: T-ALL primary samples and prototypical cell lines as well as healthy T cell counterparts were profiled by in-situ Hi-C, RNA-Seq and CTC...
grantNumber: CA193419
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE115895
manifestation:
specimenCount: 8
yearProcessed: 2019
countryOfOrigin:
individualCount: 8
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE115895
includedInDataCatalog:

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