GSE131980

syn77079530

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-020-16170-3
title: Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer [Exome]
funder: NIH-NCI
series:
creator: Ge Jennifer Michor Franziska Polyak Kornelia
license: CC-BY 4.0
species: Homo sapiens Mus musculus
studyId: syn7349757
subject:
ageGroup:
citation: Ge JY et al. (2020). Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer. Nat Commun. 11(1):2350. doi: 10.1038/s41467-020-16170-3
dataType: genomic variants
keywords:
accessType: Open Access
contributor:
description: BET inhibitors are promising therapeutic agents for the treatment of triple-negative breast cancer (TNBC), but the rapid emergence of resistance necessitates investigation of combination therapies and their effects on tumor evolution. Here, we show that palbociclib, a CDK4/6 inhibitor, and paclitaxel, a microtubule inhibitor, synergize with the BET inhibitor JQ1 in TNBC lines. High-complexity DNA barcoding and mathematical modeling indicate a high rate of de novo acquired resistance to these ...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE131980
manifestation:
specimenCount: 23
yearProcessed: 2019
countryOfOrigin:
individualCount: 23
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: whole exome sequencing
externalRepositoryUri: geo:GSE131980
includedInDataCatalog:

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