GSE131026

syn77078541

Created By Aditya Nath aditya.nath

doi: 10.1016/j.molcel.2020.04.027
title: Synthetic lethal and resistance interactions with BET bromodomain inhibitors [ATAC-Seq]
funder: NIH-NCI
series:
creator: Shu Shaokun Wu Hua-Jun Michor Franziska Polyak Kornelia
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349757
subject: SUM159
ageGroup:
citation: Shu S et al. (2020). Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Mol Cell. 78(6):1096-1113.e8. doi: 10.1016/j.molcel.2020.04.027
dataType: chromatin activity
keywords: SUM159
accessType: Open Access
contributor:
description: BET bromodomain inhibitors (BBDI) are promising therapeutic agents in triple-negative breast cancer (TNBC). However, not all tumors respond and acquired resistance emerges rapidly even in the responders. Using CRISPR and small molecule inhibitor screens combined with comprehensive molecular profiling of BBDI response and resistance in TNBC cell lines, we identified numerous synthetic lethal interactions with BBDIs as well as genes that when deleted confer resistance. The most prominent and co...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE131026
manifestation:
specimenCount: 16
yearProcessed: 2019
countryOfOrigin:
individualCount: 16
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ATAC-seq
externalRepositoryUri: geo:GSE131026
includedInDataCatalog:

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