GSE131091

syn77078466

Created By Aditya Nath aditya.nath

doi: 10.1016/j.molcel.2020.04.027
title: Synthetic lethal and resistance interactions with BET bromodomain inhibitors [CRISPR screen]
funder: NIH-NCI
series:
creator: Shu Shaokun Wu Hua-Jun Michor Franziska Polyak Kornelia
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349757
subject:
ageGroup:
citation: Shu S et al. (2020). Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Mol Cell. 78(6):1096-1113.e8. doi: 10.1016/j.molcel.2020.04.027
dataType: genomic variants
keywords:
accessType: Open Access
contributor:
description: BET bromodomain inhibitors (BBDI) are promising therapeutic agents in triple-negative breast cancer (TNBC). However, not all tumors respond and acquired resistance emerges rapidly even in the responders. Using CRISPR and small molecule inhibitor screens combined with comprehensive molecular profiling of BBDI response and resistance in TNBC cell lines, we identified numerous synthetic lethal interactions with BBDIs as well as genes that when deleted confer resistance. The most prominent and co...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE131091
manifestation:
specimenCount: 44
yearProcessed: 2019
countryOfOrigin:
individualCount: 44
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: whole genome sequencing
externalRepositoryUri: geo:GSE131091
includedInDataCatalog:

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