GSE128445

syn77078195

Created By Aditya Nath aditya.nath

doi: 10.1038/s41556-020-0514-z
title: Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance [ChIP-Seq]
funder: NIH-NCI
series:
creator: Zhang Zhao Bi Mingjun Liu Zhijie
license: CC-BY 4.0
species: Homo sapiens
studyId: syn9773346
subject:
ageGroup:
citation: Bi M et al. (2020). Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance. Nat Cell Biol. 22(6):701-715. doi: 10.1038/s41556-020-0514-z
dataType: chromatin activity
keywords:
accessType: Open Access
contributor:
description: Cellular plasticity has emerged as an important mechanism of therapy resistance in cancers, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model for endocrine resistance, we show that hormone resistance is associated with enhanced cellular plasticity, indicated by a general downregulation of luminal/epithelial differentiation markers and upregulation of basal/mesenchymal invasive markers. Our extensive omics studies including GRO-seq on enh...
grantNumber: CA217297
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE128445
manifestation:
specimenCount: 52
yearProcessed: 2019
countryOfOrigin:
individualCount: 52
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ChIP-seq
externalRepositoryUri: geo:GSE128445
includedInDataCatalog:

GSE128445 page is loading…