GSE130157

syn77077217

Created By Aditya Nath aditya.nath

doi: 10.1073/pnas.1918937117
title: Signaling state and abundance of circulating immune cell subpopulations determine cancer response to immunotherapy
funder: NIH-NCI
series:
creator: Bild Andrea Pflieger Lance
license: CC-BY 4.0
species: Homo sapiens
studyId: syn9771796
subject:
ageGroup:
citation: Griffiths JI et al. (2020). Circulating immune cell phenotype dynamics reflect the strength of tumor-immune cell interactions in patients during immunotherapy. Proc Natl Acad Sci U S A. 117(27):16072-16082. doi: 10.1073/pnas.1918937117
dataType: gene expression
keywords: PBMC single cell
accessType: Open Access
contributor:
description: We profiled 70,781 peripheral immune cells taken before, during, and after treatment with chemotherapy and immunotherapy of patients with advanced gastrointestinal cancers using single cell RNA sequencing. Prior to therapy, responders had a higher relative abundance of undifferentiated (naïve) CD4+ T cells, while non-responders had more differentiated CD4+ and CD8+ effector memory (EM) cells. Further, the EM cells present in responders were exhausted, suggesting prior recognition of tumor. ...
grantNumber: CA209978
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE130157
manifestation:
specimenCount: 44
yearProcessed: 2019
countryOfOrigin:
individualCount: 44
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE130157
includedInDataCatalog:

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