GSE123515

syn77076747

Created By Aditya Nath aditya.nath

doi: 10.1038/s41586-019-1154-y
title: Single-Cell Transcriptomes of the Regenerating Intestine Reveal a Revival Stem Cell [part 2]
funder: NIH-NCI
series:
creator: Ayyaz Arshad Kumar Sandeep Sangiorgi Bruno Ghoshal Bibaswan Gosio Jessica Ouladan Shaida Fink Mardi Barutcu Seda Trcka Daniel Shen Jess Chan Kin Wrana Jeffrey Gregorieff Alex
license: CC-BY 4.0
species: Mus musculus
studyId: syn7315805
subject: Tg(Clu-EGFP)OD95Gsat
ageGroup:
citation: Ayyaz A et al. (2019). Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature. 569(7754):121-125. doi: 10.1038/s41586-019-1154-y
dataType: gene expression
keywords: FACS sorted intestinal epithelial cells Tg(Clu-EGFP)OD95Gsat
accessType: Open Access
contributor:
description: The weekly turnover of the intestinal epithelium is driven by multipotent, Lgr5+, crypt base columnar cells (CBCs). In response to injury, however, Lgr5+ cells are lost but then re-emerge and are required for successful recovery. How these resurgent Lgr5+ stem cells arise is unclear. We transcriptionally profiled single cells from regenerating intestinal epithelia and identified a unique cell type we term the revival stem cell (rSC). rSCs are mutually exclusive to CBCs and are distinguished b...
grantNumber: CA209975
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE123515
manifestation:
specimenCount: 192
yearProcessed: 2018
countryOfOrigin:
individualCount: 192
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE123515
includedInDataCatalog:

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