GSE117783

syn77076317

Created By Aditya Nath aditya.nath

doi: 10.1038/s43018-019-0006-x
title: Single-Cell Transcriptomes of the Regenerating Intestine Reveal a Revival Stem Cell [part 1]
funder: NIH-NCI
series:
authors: Ayyaz Arshad Kumar Sandeep Sangiorgi Bruno Ghoshal Bibaswan Trcka Daniel Wrana Jeffrey Gregorieff Alex
creator: Ayyaz Arshad Kumar Sandeep Sangiorgi Bruno Ghoshal Bibaswan Trcka Daniel Wrana Jeffrey Gregorieff Alex
license: CC-BY 4.0
species: Mus musculus
studyId: syn7315805
subject: Crl:CD1(ICR)
ageGroup:
citation: Ganesh K et al. (2020). L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nat Cancer. 1(1):28-45. doi: 10.1038/s43018-019-0006-x
dataType: gene expression
keywords: All epithelial cells Crl:CD1(ICR)
accessType: Open Access
contributor:
description: The weekly turnover of the intestinal epithelium is driven by multipotent, Lgr5+, crypt base columnar cells (CBCs). In response to injury, however, Lgr5+ cells are lost but then re-emerge and are required for successful recovery. How these resurgent Lgr5+ stem cells arise is unclear. We transcriptionally profiled single cells from regenerating intestinal epithelia and identified a unique cell type we term the revival stem cell (rSC). rSCs are mutually exclusive to CBCs and are distinguished b...
grantNumber: CA209975
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE117783
manifestation:
specimenCount: 4
yearProcessed: 2018
countryOfOrigin:
individualCount: 4
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE117783
includedInDataCatalog:

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